SS-31

Description

SS-31 is a research-grade peptide from the Szeto–Schiller class designed to concentrate in mitochondria and interact with cardiolipin. By modulating cardiolipin–protein interactions, SS-31 helps preserve electron-transport efficiency and membrane organization, enabling precise interrogation of mitochondrial function under metabolic or oxidative stress.

Research Significance
Selective cardiolipin binding at the inner mitochondrial membrane; supports cristae integrity and ETC coupling.
Decreases mitochondrial ROS and enhances ATP output across multiple preclinical systems.
Widely used in models of ischemia–reperfusion injury, heart failure, renal injury, and neuroinflammation to probe mitochondrial mechanisms and resilience.

Potential Research Applications
Bioenergetics assays (OXPHOS efficiency, membrane potential, ROS generation) under oxidative or inflammatory load.
Structure–function studies of cardiolipin–ETC interactions and mitochondrial ultrastructure.
Disease-model investigations where mitochondrial dysfunction is implicated (e.g., cardiac, renal, neural).

Specifications
Form: Lyophilized peptide powder
Content: SS-31 (Elamipretide) 10 mg per vial
Identity: Tetrapeptide; sequence D-Arg-Dmt-Lys-Phe-NH₂ (Dmt = 2′,6′-dimethyl-L-tyrosine)
Storage: Store at −20 °C; once reconstituted, use promptly under sterile lab conditions.